Synthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety

Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure the compound was characterized and confirmed by using FT-IR 1H-NMR spectroscopy.
 
 desired tested against gram-positive gram-negative bacteria agar well-diffusion technique for their ability as antibacterial agent showed good activity bacteria. In addition, ADME evaluations were performed Swiss to predict if synthesized can be given orally, bioavailability, topological polar surface area, drug-likeness. result that all compounds absorbed orally fulfilled Lipinski rule.